Richard L. Apodaca

Current Position

Founder, Metamolecular, LLC.

Education and Work Experience

Available from Linkedin.

Published Papers

  1. Timmons, A.; Seierstad, M.; Apodaca, R.; Epperson, M.; Pippel, D.; Brown, S.; Chang, L.; Scott, B.; Webb, M.; Chaplan, S.R.; Breitenbucher, J.G. Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH) Bioorg. Med. Chem. Lett. 2008, 18, 2109-2113.

  2. Romero, F.A.; Du, W.; Hwang, I.; Rayl, T.J.; Kimball, F. S.; Leung, D.; Hoover, H.S.; Apodaca, R.L.; Breitenbucher, J.G.; Cravatt, B.F.; Boger, D. L. Potent and Selective α-Ketoheterocycle-Based Inhibitors of the Anandamide and Oleamide Catabolizing Enzyme, Fatty Acid Amide Hydrolase J. Med. Chem. 2007, 50, 1058-1068.

  3. Swanson, D.M.; Wilson, S.J.; Boggs, J.D.; Xiao, W.; Apodaca, R.; Barbier, A.J.; Lovenberg, T.W.; Carruthers, N.I. Aplysamine-1 and Related Analogs as Histamine H3 Receptor Antagonists. Bioorg. Med. Chem. Lett. 2006, 16, 897-900.

  4. Dvorak, C. A.; Apodaca, R.; Barbier, A.J.; Berridge, C.W.; Wilson, S.J.; Boggs, J.D.; Xiao, W.; Lovenberg, T.W; Carruthers, N.I. 4-Phenoxypiperidines: Potent, Conformationally Restricted, Non-Imidazole Histamine H3 Antagonists. J. Med. Chem. 2005, 48, 2229-2238.

  5. Barbier, A.J.; Berridge, C.; Dugovic, C.; Laposky, A.D.; Wilson, S.J.; Boggs, J.; Aluisio, L.; Lord, B.; Mazur, C.; Pudiak, C.M.; Langlois, X.; Xiao, W.; Apodaca, R.; Carruthers, N.I.; Lovenberg, T.W. Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist. Br. J. Pharmacol. 2004, 143, 649-661.

  6. Apodaca, Richard; Dvorak, Curt A.; Xiao, Wei; Barbier, Ann J.; Boggs, Jamin D.; Wilson, Sandy J.; Lovenberg, Timothy W.; Carruthers, Nicholas I. A New Class of Diamine-Based Human Histamine H3 Receptor Antagonists: 4-(Aminoalkoxy)benzylamines. J. Med. Chem. 2003, 46, 3938-3944.

  7. Apodaca, R.; Xiao, W. Direct Reductive Amination of Aldehydes and Ketones: Catalysis by Dibutyltin Dichloride. Org. Lett. 2001, 3, 1745-1748.

  8. Lynch, Vincent M.; Apodaca, Richard; Whitesell, James K.; Chou, Ming I. Trans-(R,R)-2,2'-(cyclopenta-1,2-diyl)diphenyl bis[(R)-O-methylmandelate]. Acta Crystallographica, Section C: Crystal Structure Communications 1998, 10, C54.

  9. Apodaca R. Comprehensive Organic Functional Group Transformations. (Book Review) J. Am. Chem Soc. 1997, 119, 2343.

  10. Whitesell, J.K.; Apodaca, R. Synthesis and Resolution of a New Chiral C2‑Symmetrical Bisphenol: trans-1,2-Bis(2-hydroxyphenyl)cyclopentane. Tetrahedron Lett. 1997, 38, 2589-2592.

  11. Whitesell, J.K.; Apodaca, R. A Convenient Synthesis of Protected and Free Homallylic Alcohols: Catalytic Use of Dibutyltin Dichloride in the Allylation of Aldehydes with Allyltributyltin. Tetrahedron Lett. 1996, 37, 3955-3958.

  12. Whitesell, J.K.; Apodaca, R. Trimethylsilylcyanation of Aldehydes and Ketones Catalyzed by Diorganotin Dichlorides. Tetrahedron Lett. 1996, 37, 2525-2528.

Open Source Software

  1. Rubidium. Cheminformatics scripting environment for Ruby. Project lead and co-developer.

  2. OpenBabel. Co-developed Ruby Open Babel interface.

  3. Chemistry Development Kit (CDK). Member of CDK News editorial board.

  4. InChI. Developed a pure Java implementation of IUPAC/NIST toolkit using NestedVM.

  5. Ruby CDK. Ruby interface to the Chemistry Development Kit. Project lead.

  6. Ninja. InChI reader framework written in Java. Project lead.

  7. Octet. Molecular representation framework written in Java. Project lead.

  8. Structure. 2D Molecular rendering framework for Octet and CDK written in Java. Project lead.

  9. Rosetta. Molecular language interconversion toolkit written in Java. Project lead.

  10. CDKTools. Octet-CDK compatibility layer. Project lead.