Cheminformatics Puzzler #2: Planar Chiral Paracyclophanes

Posted by Rich Apodaca Thu, 01 May 2008 13:25:00 GMT

Source: Duan, Ma, Xia, Liu, Ma, and Sun J. Org. Chem.

Without using 3D coordinates, represent the chirality of this class of planar chiral paracyclophanes (hint).

Cheminformatics Puzzler #1

Posted by Rich Apodaca Thu, 20 Mar 2008 13:16:00 GMT

How can the above atropisomers be represented without using explicit 3D coordinates?

Source: Clayden, Worrall, Moran, and Helliwell Angew. Chem. Int. Ed.